Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10927093 | Cellular Immunology | 2005 | 10 Pages |
Abstract
We investigated the circulating cytotoxic CD160+ CD8high subset in correlation to antiviral immunity and response to highly active antiretroviral therapy (HAART) in HIV+ subjects. The study included 45 treatment-naive patients receiving HAART for 18 months, retrospectively defined as good (n = 29) and transient (n = 16) responders. HIV-specific CD8 T lymphocyte levels were measured by IFNγ production in response to p17 Gag, in the presence of immobilized anti-CD160 mAb. We report a significantly increased baseline level of CD160+ CD8high subset in good therapy responders. CD160+ CD8high subset correlates with CD4+ T cell count, immune activation, and viral load. CD160+ CD8high lymphocytes contain a high amount of Granzyme B and include virus-specific T lymphocytes in HIV-1+ subjects. Co-stimulation through CD160 molecules enhances IFNγ production in response to p17 Gag. Therefore, the CD160+ CD8high subset may be useful for monitoring of virus-specific cellular immunity and predicting response to antiretroviral therapy in chronic HIV-1 infection.
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Authors
Maria H. Nikolova, Maria N. Muhtarova, Hristo B. Taskov, Kostadin Kostov, Ljubomir Vezenkov, Antoaneta Mihova, Laurence Boumsell, Armand Bensussan,