Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10927107 | Cellular Immunology | 2005 | 5 Pages |
Abstract
This study explored the effect of hyperthyroid state on humoral immune response and NF-κB signaling in lymphocytes. Male Wistar rats were treated with l-thyroxin for four weeks. Animals were immunized with sheep red blood cells (SRBC) after three weeks of l-thyroxin treatment. After one week of immunization, serum anti-SRBC titer was measured and NF-κB signaling was studied in lymphocytes by Western blot analysis of p-IKB-α, IKB-α, and p65. These results were compared with that of control rats. Antibody response and density of p-IKB-α and p65 were significantly higher in l-thyroxin treated rats in comparison to controls. The antibody response was found to have significant correlation with density of p-IKB-α and p65. Our results indicate that NF-κB signaling pathway in lymphocytes is activated in hyperthyroid state which might play a role in potentiation of antibody response.
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Authors
R. Vinayagamoorthi, Bidhan Chandra Koner, S. Kavitha, D.N. Nandakumar, P. Padma Priya, Kalyan Goswami,