Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10927161 | Cellular Immunology | 2005 | 6 Pages |
Abstract
The small Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 have distinct roles in regulating neutrophil chemotaxis; however, little is known about their possible unique roles in mediating bacterial killing. To elucidate the relative roles of Rac1 and Rac2 in regulating neutrophil-mediated bacterial killing, we utilized the previously described mice model in which mouse neutrophils are deficient in either Rac1, Rac2, or both isoforms. We demonstrate here that while both Rac isoforms are required for normal neutrophil chemotaxis and bacterial killing, they have non-overlapping roles in bacterial phagocytosis and NADPH oxidase function.
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Authors
Adeline Loo Yee Koh, Chun Xiang Sun, Fei Zhu, Michael Glogauer,