Article ID Journal Published Year Pages File Type
10929131 Current Opinion in Cell Biology 2012 7 Pages PDF
Abstract
Aging brings about numerous cellular defects. Amongst the most prominent are elevated levels of persistent DNA damage, changes to chromatin structure and epigenetic modifications, and alterations of global transcription programs. These are not independent events and recent work begins to shed light on the intricate interplay between these aging-related defects.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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DNA damage, chromatin, and transcription: the trinity of aging
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