Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10929141 | Current Opinion in Cell Biology | 2012 | 5 Pages |
Abstract
⺠Telomeres shorten with age in humans. ⺠Whether the consequences of telomere dysfunction in naturally ageing individuals is the limiting factor in maintenance of tissue homeostasis, therefore directing the ageing phenomena is not known. ⺠Most studies in the lab use mouse models that do not rely on telomeres as a cell division control mechanism. ⺠It is timely to identify complementary vertebrate models that, like humans, have restricted telomerase activity and have telomere length as a cell division clock.
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Authors
Catarina M Henriques, Miguel Godinho Ferreira,