Article ID Journal Published Year Pages File Type
10929141 Current Opinion in Cell Biology 2012 5 Pages PDF
Abstract
► Telomeres shorten with age in humans. ► Whether the consequences of telomere dysfunction in naturally ageing individuals is the limiting factor in maintenance of tissue homeostasis, therefore directing the ageing phenomena is not known. ► Most studies in the lab use mouse models that do not rely on telomeres as a cell division control mechanism. ► It is timely to identify complementary vertebrate models that, like humans, have restricted telomerase activity and have telomere length as a cell division clock.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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