Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche

► ECM molecules bind specific growth factors and morphogens regulating their bioavailability, and organizing a dynamic microenvironment for local integration of adhesive and growth factor signalling. ► Integrins, the major receptors for ECM proteins, exert an extensive crosstalk with growth factor and cytokine receptors that generates an intracellular network of signalling pathways and modulates key aspects of cell behaviour. ► ECM proteins/integrins are key components shaping the stem cell niche to maintain stem cell homeostasis and to direct lineage commitment.