Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10929221 | Current Opinion in Cell Biology | 2010 | 7 Pages |
Abstract
Multicellular organisms have evolved highly sophisticated machinery to that their genomes are accurately duplicated and that the various gene expression programs are established correctly. Recent large-scale studies have shed light on how these fundamental processes interact. Although the machinery mediating these processes share similar cis-regulatory elements, they are not strictly coregulated. Furthermore, studies of the replisome show that highly transcribed genes present a major obstacle to its operation. Further studies will be needed to identify key regulators of the spatio-temporal program of DNA replication, for the elucidation of the complex interplay between replication and transcription.
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Authors
Chrystelle Maric, Marie-Noƫlle Prioleau,