Yeast chromosomal interactions and nuclear architecture

Biology is essentially the study of networks of interactions within or between organisms. The study of chromosomal interactions, while still in its infancy, is providing insights that enable us to study genome biology as a network of inter-linked systems and not simply as the isolated loci we were previously restricted to. Recent work has highlighted how chromosomal interactions, nuclear position and genomic function are inter-linked. This review will start by outlining how chromosomal interactions are determined. It will continue to discuss recent observations of intra-chromosomal and inter-chromosomal interactions in yeast, interactions involving foreign DNA and the formation of chromosomal interactions. The review will then conclude with a model to explain the formation of yeast chromosomal interactions and consequently yeast interphase nuclear structure.