| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10929318 | Current Opinion in Cell Biology | 2012 | 9 Pages |
Abstract
⺠In CD4+ T cells changes in cellular fate are precise yet contain stochastic elements. ⺠Cell-to-cell variation in abundance of molecules represents 'noise.' ⺠Sources of noise include transcription, network topology and signaling environments. ⺠Transcriptional noise may include leaky expression of lowly expressed transcripts. ⺠Epigenetic marks (e.g. bivalent histone marks) may correlate with gene noise profiles.
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Authors
Daniel Hebenstreit, Andrew Deonarine, M Madan Babu, Sarah A Teichmann,