Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10929340 | Current Opinion in Cell Biology | 2011 | 6 Pages |
Abstract
As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current view of the NPC as a dynamic hub for the integration of chromatin regulation and nuclear trafficking and discuss the functional interplay between nucleoporins and the nuclear genome.
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Authors
Yun Liang, Martin W Hetzer,