Article ID Journal Published Year Pages File Type
10929340 Current Opinion in Cell Biology 2011 6 Pages PDF
Abstract
As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current view of the NPC as a dynamic hub for the integration of chromatin regulation and nuclear trafficking and discuss the functional interplay between nucleoporins and the nuclear genome.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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