| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10929345 | Current Opinion in Cell Biology | 2011 | 7 Pages |
Abstract
Accurate chromosome segregation requires the interaction of chromosomes with the microtubules from the mitotic spindle. This interaction is mediated by the macro-molecular kinetochore complex, which assembles only at the centromeric region of each chromosome. However, how this site is specified and how assembly of the kinetochore structure is regulated in coordination with cell cycle progression remains unclear. Recent studies have begun to shed light on the mechanisms underlying assembly of this complex structure.
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Authors
Karen E Gascoigne, Iain M Cheeseman,