| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10929390 | Current Opinion in Cell Biology | 2008 | 8 Pages |
Abstract
Recent studies in vertebrate and invertebrate model organisms uncover the importance of endocytosis for biased signaling during asymmetric cell division. In stem cells, perturbing polarity and asymmetric division affect their selfrenewal causing exponential proliferation, thereby giving rise to cancer. An emerging pattern is that endocytosis controls asymmetric cell division, which underlies stem cell selfrenewal and defective selfrenewal is on the basis of tumorigenesis caused by cancer stem cells.
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Authors
Franck Coumailleau, Marcos González-Gaitán,