Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10929399 | Current Opinion in Cell Biology | 2008 | 6 Pages |
Abstract
The extracellular matrix (ECM) glycoprotein fibronectin (FN) requires the help of cells to assemble into a functional fibrillar matrix, which then orchestrates the assembly of other ECM proteins and promotes cell adhesion, migration and signalling. Fibrillogenesis is initiated and governed by cell surface integrins that bind to specific sites in the FN molecule. Recent studies identified novel integrin binding sites in FN that can also participate in FN fibril formation and in morphogenetic events during development.
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Authors
Michael Leiss, Karsten Beckmann, Amparo Girós, Mercedes Costell, Reinhard Fässler,