Article ID Journal Published Year Pages File Type
10929405 Current Opinion in Cell Biology 2008 10 Pages PDF
Abstract
Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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