Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10929405 | Current Opinion in Cell Biology | 2008 | 10 Pages |
Abstract
Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Mohsen Sabouri-Ghomi, Yi Wu, Klaus Hahn, Gaudenz Danuser,