Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10929814 | Current Opinion in Cell Biology | 2005 | 6 Pages |
Abstract
Dynein is a minus-end-directed microtubule motor crucial to diverse cellular processes. The unwieldy size of the molecule and the difficulty of expressing and purifying mutants have hampered mechanistic studies of dynein. Recent progress sheds light on key unsolved questions concerning how the molecule is really organized, what conformational changes accompany ATP hydrolysis and whether two or three motor domains are coordinated in their motion.
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Authors
Kazuhiro Oiwa, Hitoshi Sakakibara,