Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10930086 | Cytokine & Growth Factor Reviews | 2014 | 8 Pages |
Abstract
Innate pattern recognition receptors NLRs are cytosolic sensors that detect endogenous metabolic stress and form a multiprotein complex called the inflammasome, that recruits and activates caspase enzymes mediating the activation of the cytokines IL-1β and IL-18. The innate immune system and metabolic system are evolutionarily conserved, intimately integrated, and functionally dependent. In recent decades, obesity-associated metabolic diseases have been become a worldwide epidemic. Here we review recent evidence that demonstrates the important roles of NLRs and inflammasomes in response to metabolic stress in different tissues.
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Authors
Hua-Bing Li, Chengcheng Jin, Yuanyuan Chen, Richard A. Flavell,