Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10930355 | Cytotherapy | 2016 | 7 Pages |
Abstract
This study is the first report to show that T cells specific for a leukemia-associated antigen are found at a significantly higher frequency in UCB than adult blood. Our results also demonstrate specific cytotoxicity of expanded UCB-derived PR1-CTLs against PR1-expressing targets. Together, our data suggest that UCB PR1-CTLs could be useful to prevent or treat leukemia relapse in myeloid leukemia patients.
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Authors
Lisa S. St. John, Liping Wan, Hong He, Haven R. Garber, Karen Clise-Dwyer, Gheath Alatrash, Katayoun Rezvani, Elizabeth J. Shpall, Catherine M. Bollard, Qing Ma, Jeffrey J. Molldrem,