Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10930357 | Cytotherapy | 2016 | 13 Pages |
Abstract
This study demonstrates that human amniotic epithelial cells conditioned medium could down-regulate the expression of fibrosis-related molecules by regulating MMP and tissue inhibitor of metalloproteinase levels, and suppress TGF-β1-induced fibroblast transition, in which the TGF-β1/Smad3 pathway is likely involved. These findings suggest that human amniotic epithelial cells are a potential therapeutic compound for the treatment of keloids.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Bin Zhao, Jia-Qi Liu, Chen Yang, Zhao Zheng, Qin Zhou, Hao Guan, Lin-Lin Su, Da-Hai Hu,