Article ID Journal Published Year Pages File Type
10930406 Cytotherapy 2014 12 Pages PDF
Abstract
A physiologically relevant microenvironment of 5% O2 rejuvenates WJ-MSC culture toward less-differentiated, more primitive and faster-growing phenotypes with involvement of HIF-1α and HIF-2α-mediated and TSA-sensitive chromatin modification mechanisms. These observations add to the understanding of MSC responses to defined culture conditions, which is the most critical issue for adult stem cells translational applications.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Authors
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