Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10930406 | Cytotherapy | 2014 | 12 Pages |
Abstract
A physiologically relevant microenvironment of 5% O2 rejuvenates WJ-MSC culture toward less-differentiated, more primitive and faster-growing phenotypes with involvement of HIF-1α and HIF-2α-mediated and TSA-sensitive chromatin modification mechanisms. These observations add to the understanding of MSC responses to defined culture conditions, which is the most critical issue for adult stem cells translational applications.
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Authors
Katarzyna Drela, Anna Sarnowska, Patrycja Siedlecka, Ilona Szablowska-Gadomska, Miroslaw Wielgos, Marcin Jurga, Barbara Lukomska, Krystyna Domanska-Janik,