Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10930665 | Cytotherapy | 2005 | 5 Pages |
Abstract
The subpopulation of CD4 CD25 immunoregulatory T cells constitutes less than of the entire CD4 T-cell pool in mice and in humans. These cells play a crucial role in the control of autoimmune processes. More recently, in vitro and in vivo data also indicate that CD4 CD25 immunoregulatory T cells can regulate alloreactivity. This renders them good candidates for innovative strategies in the field of transplantation. Inducing a state of immune tolerance with immunoregulatory T cells would alleviate the need for immunosuppression, and the occurrence of late allograft failure represents a major goal of transplantation immunology. Here we discuss how these naturally occurring CD4 CD25 immunoregulatory T cells can be used to modulate alloreactivity in hematopoietic stem cell and solid organ transplantation.
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Authors
J.L. Cohen, B.L. Salomon,