Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10932176 | Developmental Biology | 2013 | 13 Pages |
Abstract
⺠We present a quantitative analysis of spatial gene expression in Drosophila mutants. ⺠Dynamic gap domain shifts do not depend on expression of terminal gap genes or hb. ⺠Expression variability is greatly increased in a tll mutant background. ⺠This indicates de-canalisation (loss of developmental robustness) in the mutant. ⺠Such de-canalisation is a common phenomenon in mutants of developmental regulators.
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Authors
Hilde Janssens, Anton Crombach, Karl Richard Wotton, Damjan Cicin-Sain, Svetlana Surkova, Chea Lu Lim, Maria Samsonova, Michael Akam, Johannes Jaeger,