Hedgehog and Wnt coordinate signaling in myogenic progenitors and regulate limb regeneration

► Shh signaling is essential for limb regeneration. ► Reduced Shh signaling does not affect the dedifferentiation process. ► Shh is required for AP patterning at early stages and for cellular expansion at later stages of regeneration. ► Wnt signaling functions downstream of Shh signaling during regeneration.