| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932197 | Developmental Biology | 2012 | 11 Pages |
Abstract
⺠Two functional domains of LON-2/glypican independently inhibit BMP signaling. ⺠The N-terminal protease product of LON-2 is sufficient for LON-2 activity. ⺠LON-2 does not require protease cleavage and heparan sulfation sites for activity. ⺠The LON-2 C-terminus with GPI and heparan sulfation sites inhibits BMP signaling. ⺠LON-2's RGD site or membrane linkage is required for LON-2 activity.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Suparna Taneja-Bageshwar, Tina L. Gumienny,