| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932198 | Developmental Biology | 2012 | 9 Pages |
Abstract
⺠We ablate Aurora A in the epiblast or visceral endoderm of mouse embryos. ⺠Aurora A ablation leads to apoptosis, patterning defects and embryo lethality. ⺠ES cells can rescue the phenotype of Aurora A deficiency in the epiblast. ⺠Embryonic defects vary depending on the tissue affected by the mutation. ⺠We provide an alternative to tetraploid complementation experiments.
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Authors
Yeonsoo Yoon, Dale O. Cowley, Judith Gallant, Stephen N. Jones, Terry Van Dyke, Jaime A. Rivera-Pérez,