Article ID Journal Published Year Pages File Type
10932205 Developmental Biology 2013 9 Pages PDF
Abstract
► Loss of HMGCR function disrupts vascular stability in developing zebrafish. ► Vascular defects are reversed with mevalonate or geranylgeranyl pyrophosphate. ► Loss of GGTase-I function phenocopies loss of HMGCR. ► The HMGCR pathway affects vascular stability via prenylation-dependent signalling.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway
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