Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10932227 | Developmental Biology | 2012 | 15 Pages |
Abstract
⺠Islet cell and endothelial cell interactions are critical for islet development. ⺠VEGF-A from developing endocrine cells is critical for islet vascularization. ⺠Increased VEGF-A increases endothelial cells, but reduces β cell mass. ⺠Increased VEGF-A impairs β cell proliferation and migration and islet formation. ⺠Angiopoietin-Tie2 signaling does not have a crucial role in islet vascularization.
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Authors
Qing Cai, Marcela Brissova, Rachel B. Reinert, Fong Cheng Pan, Priyanka Brahmachary, Marie Jeansson, Alena Shostak, Aramandla Radhika, Greg Poffenberger, Susan E. Quaggin, W. Gray Jerome, Daniel J. Dumont, Alvin C. Powers,