A functional link between localized Oskar, dynamic microtubules, and endocytosis

► Microtubule plus end binding proteins localize to the posterior of the Drosophila oocyte. ► Polarized distribution of plus end binding proteins is not required for oskar mRNA localization. ► Oskar protein is required for recruiting plus end binding proteins to the oocyte posterior. ► Polarized distribution of microtubule plus ends is required for efficient endocytosis.