Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10932234 | Developmental Biology | 2012 | 10 Pages |
Abstract
⺠KLC3 is the only kinesin light chain known to be expressed in spermatids. ⺠High level expression of KLC3 in cell culture causes mitochondrial aggregate formation in a microtubule dependent manner. ⺠High level expression of a KLC3 mutant in transgenic mice can cause midpiece abnormalities. ⺠KLC3 mutant expressing transgenic mice are subfertile and produce sperm with impaired motility.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Ying Zhang, Young Ou, Min Cheng, Habib Shojaei Saadi, Jacob C. Thundathil, Frans A. van der Hoorn,