Article ID Journal Published Year Pages File Type
10932234 Developmental Biology 2012 10 Pages PDF
Abstract
► KLC3 is the only kinesin light chain known to be expressed in spermatids. ► High level expression of KLC3 in cell culture causes mitochondrial aggregate formation in a microtubule dependent manner. ► High level expression of a KLC3 mutant in transgenic mice can cause midpiece abnormalities. ► KLC3 mutant expressing transgenic mice are subfertile and produce sperm with impaired motility.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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