Article ID Journal Published Year Pages File Type
10932326 Developmental Biology 2012 11 Pages PDF
Abstract
► Mammary tissue undergoes branching morphogenesis in response to TGFα stimulation ► TGFα activates mammary associated NHE1 exchanger activity through PI3K. ► NHE1 activation by TGFα induces rapid intracellular alkalization. ► Inhibiting NHE1 activity and alkalization leads to increased MAPK activation. ► Inhibiting NHE1 during TGFα stimulation leads to abnormal mammary development.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
Intracellular pH regulation by Na+/H+ exchanger-1 (NHE1) is required for growth factor-induced mammary branching morphogenesis
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