Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10932326 | Developmental Biology | 2012 | 11 Pages |
Abstract
⺠Mammary tissue undergoes branching morphogenesis in response to TGFα stimulation ⺠TGFα activates mammary associated NHE1 exchanger activity through PI3K. ⺠NHE1 activation by TGFα induces rapid intracellular alkalization. ⺠Inhibiting NHE1 activity and alkalization leads to increased MAPK activation. ⺠Inhibiting NHE1 during TGFα stimulation leads to abnormal mammary development.
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Authors
Edmund C. Jr., Shawon Debnath, Stephen Gundry, Sajini Gundry, Umit Uyar, Jimmie E. Fata,