Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10932332 | Developmental Biology | 2012 | 8 Pages |
Abstract
⺠Tgfbr2 is required for neural arch closure and proliferation in adjacent mesenchyme. ⺠TGFβ stimulates migration of sclerotome associated mesenchyme. ⺠TGFβ stimulates expression of Pdgfb/c, which are also reduced in Tgfbr2cko cells. ⺠PDGF signalling is required for TGFβ mediated migration. ⺠TGFβ and PDGF regulate vertebrae development through paracrine interactions.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Ying Wang, Rosa Serra,