| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932345 | Developmental Biology | 2012 | 10 Pages |
Abstract
⺠Progenitor cells revert back to form ectopic neuroblasts in lgl mutant brains. ⺠Lgl and aPKC together ensure asymmetric segregation of Numb in mitotic neuroblasts. ⺠aPKC regulates asymmetric localization of Numb via the ACBD3 binding region. ⺠Serines 48/52 are necessary for localization but dispensable for function of Numb. ⺠The ACBD3 binding region of Numb exerts neuroblast-specific suppression of Notch.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Jill M. Haenfler, Chaoyuan Kuang, Cheng-Yu Lee,