| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932359 | Developmental Biology | 2012 | 9 Pages |
Abstract
⺠Conserved non-coding elements (CNEs) linked to Sox21 contain two lens enhancers. ⺠Removal of these enhancers from a reporter BAC abolishes lens expression. ⺠Morpholino knockdown of zebrafish sox21b leads to defects in lens development. ⺠Conserved putative Sox binding sites are vital for enhancer activity in lens and CNS. ⺠CNEs are crucial for normal development and contain overlapping embryonic enhancers.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Stefan Pauls, Sarah F. Smith, Greg Elgar,