| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932364 | Developmental Biology | 2012 | 12 Pages |
Abstract
⺠This study identified sperm-egg interaction partners during mammalian fertilization. ⺠SPR analysis with sperm acrosomal SLLP1 identified the oolemmal partner, SAS1B. ⺠SAS1B is an oocyte specific metalloprotease. ⺠The gamete partners revealed high affinity interactions. ⺠SAS1B deletion in female mice showed 34% reduction in fertility.
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Authors
Monika Sachdev, Arabinda Mandal, Sabine Mulders, Laura C. Digilio, Subbarayalu Panneerdoss, Viswanadhapalli Suryavathi, Eusebio Pires, Kenneth L. Klotz, Laura Hermens, MarÃa Belén Herrero, Charles J. Flickinger, Marcel van Duin, John C. Herr,