| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932367 | Developmental Biology | 2012 | 12 Pages |
Abstract
⺠Sin3a is required for proliferation and survival of pluripotent embryonic cells. ⺠Sin3a-/- mouse ICM cells are eliminated by p53-independent apoptosis. ⺠Sin3a is a critical regulator of the unusual pluripotent embryonic cell cycle. ⺠Sin3a prevents or repairs DSBs that arise in ES cells, perhaps during replication. ⺠The Sin3a interactome provides insights into function Sin3a in ES cells.
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Authors
Patrick McDonel, Jeroen Demmers, David W.M. Tan, Fiona Watt, Brian D. Hendrich,