Article ID Journal Published Year Pages File Type
10932369 Developmental Biology 2012 10 Pages PDF
Abstract
► Serotonergic neurons differentiate in sea urchin anterior neuroectoderm. ► zinc-finger homeobox, tryptophan 5-hydroxylase (tph) and serotonin are co-expressed. ► Zinc-finger homeobox (Zfhx1/Z81) is required for tph and serotonin. ► zfhx1/z81 depends on FoxQ2, which is required for forming anterior neuroectoderm. ► Zfhx1/Z81 is an important intermediate regulator in serotonergic neurogenesis.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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Zinc finger homeobox is required for the differentiation of serotonergic neurons in the sea urchin embryo
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