| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932465 | Developmental Biology | 2011 | 11 Pages |
Abstract
⺠Hes1 null mutant mouse embryos display a neural tube closure defect and exencephaly. ⺠In the mutant midbrain, dopaminergic (DA) neurons are markedly decreased in number. ⺠In addition, many DA neurons grow dorsally and invade the rostral hindbrain. ⺠Serotonergic neurons are also ectopically located in the mutant midbrain. ⺠These anomalies may result from the defective isthmic organizer in Hes1 null mutants.
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Authors
Yoko Kameda, Takayoshi Saitoh, Takao Fujimura,