Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10932481 | Developmental Biology | 2011 | 12 Pages |
Abstract
⺠The E3 ubiquitin ligase Fbw7 is required for cerebellar development. ⺠Fbw7 deletion increases N-terminally phosphorylated c-Jun and Notch1 protein levels. ⺠Concomitant c-Jun deletion partially rescues cerebellar defects in Fbw7-mutant mice.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Anett Jandke, Clive Da Costa, Rocio Sancho, Emma Nye, Bradley Spencer-Dene, Axel Behrens,