| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932498 | Developmental Biology | 2011 | 10 Pages |
Abstract
⺠Spinal cord regenerative ability is lost with development. ⺠PAD3 (Ca++ dependent enzyme that deiminates proteins) is developmentally regulated. ⺠PAD3 increase following injury is greater in spinal cords that cannot regenerate. ⺠PAD inhibition reduces apoptosis and tissue damage in injured spinal cords. ⺠PAD/deimination are developmentally regulated modulators of secondary injury response.
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Authors
Sigrun Lange, Stefanie Gögel, Kit-Yi Leung, Bertrand Vernay, Anthony P. Nicholas, Corey P. Causey, Paul R. Thompson, Nicholas D.E. Greene, Patrizia Ferretti,