Reversible response of protein localization and microtubule organization to nutrient stress during Drosophila early oogenesis

► Functionally related proteins are selectively enriched in young Drosophila oocytes. ► Polarized transport and diffusion/trapping mechanisms contribute to oocyte enrichment. ► Polarized transport is rapidly and reversibly disrupted by nutrient stress. ► Model: slowing oocyte growth preserves young egg chambers during starvation.