| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932505 | Developmental Biology | 2011 | 12 Pages |
Abstract
⺠Fgf-signaling components and MMP genes are activated in blastemasin ALM. ⺠Fgf signaling is necessary to maintain blastema but not to activate blastemal genes. ⺠Collagenase (MMP1) treatment promoted Prrx-1(blastema marker gene). ⺠Phos-FAK and β3 integrinare correlated with ECM degradation and regulate Prrx-1. ⺠Activation of Fgf signaling and MMPs result in an induction of a blastema-like structure without the presence of a nerve.
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Authors
Akira Satoh, Aki makanae, Ayako Hirata, Yutaka Satou,