| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932528 | Developmental Biology | 2012 | 13 Pages |
Abstract
⺠We approached the embryonic role of cholesterol-rich membrane microdomains (CRMM). ⺠CRMM disruption by cholesterol depletion did not affect Spemann's organizer function. ⺠CRMM disruption affected Shh and goosecoid expression in neurula embryos. ⺠CRMM disruption generated embryos in which the prosencephalon failed to develop. ⺠Head defects caused by CRMM disruption are partially rescued by Dkk1.
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Authors
Alice H. Reis, Karla L. Almeida-Coburn, Mariana P. Louza, Débora M. Cerqueira, Diego P. Aguiar, Livia Silva-Cardoso, Fábio A. Mendes, Leonardo R. Andrade, Marcelo Einicker-Lamas, Georgia C. Atella, José M. Brito, José G. Abreu,