Article ID Journal Published Year Pages File Type
10932533 Developmental Biology 2012 10 Pages PDF
Abstract
► Orai1 is a calcium channel in the plasma membrane of oocytes. ► It mediates store-operated calcium entry upon depletion of the endoplasmic reticulum. ► The calcium influx through the Orai1 channel is essential for maintaining calcium oscillations during fertilization. ► After fertilization, oocytes lacking Orai1 form embryos with poor developmental potential.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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