Article ID Journal Published Year Pages File Type
10932545 Developmental Biology 2012 9 Pages PDF
Abstract
► Neurog3+ cells differentiate into hormone-expressing cells in 10 hours. ► Neurog3 is necessary for cell cycle exit and delamination. ► Failed endocrine progenitors differentiate into acinar cells only prior E12.5. ► Islet progenitors arise from bipotent duct/endocrine precursors after E12.5. ► Plasticity of Neurog3-induced cells varies during pancreas development.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development
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