Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10932546 | Developmental Biology | 2012 | 15 Pages |
Abstract
⺠Arginine and leucine are necessary and sufficient to induce trophoblast motility. ⺠Arginine and leucine have both mTORC1-dependent and independent actions. ⺠p70S6K or 4EBP activity do not correlate with motility suggesting a separate pathway. ⺠In vivo mTOR activation suggests uterine factors induce mTORC1 regulated motility. ⺠Amino acids may be components of the in vivo uterine-embryo implantation crosstalk.
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Authors
Isabel M. González, Patrick M. Martin, Carol Burdsal, Jennifer L. Sloan, Sela Mager, Thurl Harris, Ann E. Sutherland,