Article ID Journal Published Year Pages File Type
10932569 Developmental Biology 2011 11 Pages PDF
Abstract
► S1P1 is expressed by the blood vessels in developing endoderm. ► S1P1 ablation results in compromised growth of several foregut-derived organs. ► Reduced growth in the pancreas results from decreased proliferation of Pdx1+ cells. ► Blood vessel ablation does not mimic the S1P1−/− instead the opposite is observed. ► Hypervascularization is seen in the S1P1 mutants.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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