| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932571 | Developmental Biology | 2011 | 11 Pages |
Abstract
⺠No β-catenin activity can be detected in the early nephrogenic mesenchyme. ⺠Expressional and functional data implicate Ca2+/NFAT Wnt signalling in nephrogenesis. ⺠Disruption of the Ca2+/NFAT pathway disrupts kidney morphogenesis. ⺠Increased Ca2+ signalling partially rescues nephrogenesis in Wnt4 knockout mice. ⺠We propose Ca2+/NFAT signalling as a novel regulator of nephrogenesis.
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Authors
S.F. Burn, A. Webb, R.L. Berry, J.A. Davies, A. Ferrer-Vaquer, A.K. Hadjantonakis, N.D. Hastie, P. Hohenstein,