| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932574 | Developmental Biology | 2011 | 12 Pages |
Abstract
⺠Crescent is a dorsally secreted Frizzled-Related Protein (sFRP), related to Sizzled, expressed in the developing gastrula and known to regulate Wnt signaling. ⺠We now report that Crescent also regulates the BMP pathway required for Dorsal-Ventral (D-V) patterning. ⺠Crescent regulates the Chordin/BMP pathway by competitively inhibiting Tolloid proteinases, the enzymes that degrade Chordin. ⺠We propose that Crescent and Sizzled cooperate in vivo, from opposite poles of the embryo, to fine-tune the D-V BMP signaling gradient during development.
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Authors
Diego Ploper, Hojoon X. Lee, Edward M. De Robertis,