| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932579 | Developmental Biology | 2011 | 11 Pages |
Abstract
⺠We generated a gain-of-function Hoxb3Tg transgenic mutant which expressed Hoxb3 in hindbrain r4. ⺠Hoxb3Tg embryos lost Hoxb1 expression in the mutant r4 and phenocopy Hoxb1 null mutants. ⺠By molecular analyses we showed that Hoxb3 can suppress Hoxb1 expression directly. ⺠We demonstrated that Hoxb3 can restrict Hoxb1 expression to r4 by a negative regulatory mechanism.
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Authors
Elaine Y.M. Wong, Xing An Wang, Siu Shan Mak, Jearn Jang Sae-Pang, Kam Wing Ling, Bernd Fritzsch, Mai Har Sham,