Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers

► Peraiaxin, a PDZ domain protein exhibits lens specific expression within the eye. ► Periaxin exhibits maturation dependent redistribution in lens fibers. ► Periaxin exists in a macromolecular complex and regulates membrane organization. ► Periaxin null lenses reveal disruptions in fiber cell shape and membrane stability. ► Periaxin plays a key role in membrane stability of lens fiber cells.