Article ID Journal Published Year Pages File Type
10932607 Developmental Biology 2011 10 Pages PDF
Abstract
► Beta-catenin controls neuroepithelial integrity and differentiation in midbrain. ► Loss of beta-catenin de-regulates mitotic spindle orientation. ► This leads to premature differentiation of neuroepithelial progenitors. ► GSK3 phosphorylated beta-catenin localizes to centrosomes of progenitors.►It is required for apical-basal polarity and centrosome maintenance.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain
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